Pesquisa | BVS IEC

1.

An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis.

Hino, Tomohiro; Omura, Satoshi N; Nakagawa, Ryoya; Togashi, Tomoki; Takeda, Satoru N; Hiramoto, Takafumi; Tasaka, Satoshi; Hirano, Hisato; Tokuyama, Takeshi; Uosaki, Hideki; Ishiguro, Soh; Kagieva, Madina; Yamano, Hiroyuki; Ozaki, Yuki; Motooka, Daisuke; Mori, Hideto; Kirita, Yuhei; Kise, Yoshiaki; Itoh, Yuzuru; Matoba, Satoaki; Aburatani, Hiroyuki; Yachie, Nozomu; Karvelis, Tautvydas; Siksnys, Virginijus; Ohmori, Tsukasa; Hoshino, Atsushi; Nureki, Osamu.

Cell ; 186(22): 4920-4935.e23, 2023 10 26.

Artigo em Inglês | MEDLINE | ID: mdl-37776859

2.

Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast.

Asanuma, Takahiro; Inagaki, Soichi; Kakutani, Tetsuji; Aburatani, Hiroyuki; Murakami, Yota.

Genes Dev ; 36(21-24): 1145-1159, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-36617881

3.

NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis.

Hiraike, Yuta; Saito, Kaede; Oguchi, Misato; Wada, Takahito; Toda, Gotaro; Tsutsumi, Shuichi; Bando, Kana; Sagawa, Junji; Nagano, Gaku; Ohno, Haruya; Kubota, Naoto; Kubota, Tetsuya; Aburatani, Hiroyuki; Kadowaki, Takashi; Waki, Hironori; Yanagimoto, Shintaro; Yamauchi, Toshimasa.

Proc Natl Acad Sci U S A ; 120(31): e2308750120, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37487068

4.

Region-specific DNA hydroxymethylation along the malignant progression of IDH-mutant gliomas.

Hana, Taijun; Mukasa, Akitake; Nomura, Masashi; Nagae, Genta; Yamamoto, Shogo; Tatsuno, Kenji; Ueda, Hiroki; Fukuda, Shiro; Umeda, Takayoshi; Tanaka, Shota; Nejo, Takahide; Kitagawa, Yosuke; Yamazawa, Erika; Takahashi, Satoshi; Koike, Tsukasa; Kushihara, Yoshihiro; Takami, Hirokazu; Takayanagi, Shunsaku; Aburatani, Hiroyuki; Saito, Nobuhito.

Cancer Sci ; 115(5): 1706-1717, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38433527

5.

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells.

Higashijima, Yoshiki; Matsui, Yusuke; Shimamura, Teppei; Nakaki, Ryo; Nagai, Nao; Tsutsumi, Shuichi; Abe, Yohei; Link, Verena M; Osaka, Mizuko; Yoshida, Masayuki; Watanabe, Ryo; Tanaka, Toshihiro; Taguchi, Akashi; Miura, Mai; Ruan, Xiaoan; Li, Guoliang; Inoue, Tsuyoshi; Nangaku, Masaomi; Kimura, Hiroshi; Furukawa, Tetsushi; Aburatani, Hiroyuki; Wada, Youichiro; Ruan, Yijun; Glass, Christopher K; Kanki, Yasuharu.

EMBO J ; 39(7): e103949, 2020 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-32125007

6.

Loss of viral genome with altered immune microenvironment during tumour progression of Epstein-Barr virus-associated gastric carcinoma.

Kondo, Atsushi; Shinozaki-Ushiku, Aya; Rokutan, Hirofumi; Kunita, Akiko; Ikemura, Masako; Yamashita, Hiroharu; Seto, Yasuyuki; Nagae, Genta; Tatsuno, Kenji; Aburatani, Hiroyuki; Koinuma, Daizo; Ushiku, Tetsuo.

J Pathol ; 260(2): 124-136, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-36806225

7.

PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt.

Kawase, Tatsuya; Ohki, Rieko; Shibata, Tatsuhiro; Tsutsumi, Shuichi; Kamimura, Naoko; Inazawa, Johji; Ohta, Tsutomu; Ichikawa, Hitoshi; Aburatani, Hiroyuki; Tashiro, Fumio; Taya, Yoichi.

Cell ; 136(3): 535-50, 2009 Feb 06.

Artigo em Inglês | MEDLINE | ID: mdl-19203586

8.

Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.

Aihara, Hitoshi; Nakagawa, Takeya; Mizusaki, Hirofumi; Yoneda, Mitsuhiro; Kato, Masanori; Doiguchi, Masamichi; Imamura, Yuko; Higashi, Miki; Ikura, Tsuyoshi; Hayashi, Tomonori; Kodama, Yoshiaki; Oki, Masaya; Nakayama, Toshiyuki; Cheung, Edwin; Aburatani, Hiroyuki; Takayama, Ken-Ichi; Koseki, Haruhiko; Inoue, Satoshi; Takeshima, Yukio; Ito, Takashi.

Mol Cell ; 64(1): 176-188, 2016 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-27716482

9.

Dramatic response to entrectinib in a patient with malignant peripheral nerve sheath tumor harboring novel SNRNP70-NTRK3 fusion gene.

Kobayashi, Hiroshi; Makise, Naohiro; Shinozaki-Ushiku, Aya; Zhang, Liuzhe; Ishibashi, Yuki; Ikegami, Masachika; Tsuda, Yusuke; Kohsaka, Shinji; Ushiku, Tetsuo; Oda, Katsutoshi; Miyagawa, Kiyoshi; Aburatani, Hiroyuki; Mano, Hiroyuki; Tanaka, Sakae.

Genes Chromosomes Cancer ; 62(1): 47-51, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-35906852

10.

Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan.

Kage, Hidenori; Shinozaki-Ushiku, Aya; Ishigaki, Kazunaga; Sato, Yusuke; Tanabe, Masahiko; Tanaka, Shota; Tanikawa, Michihiro; Watanabe, Kousuke; Kato, Shingo; Akagi, Kiwamu; Uchino, Keita; Mitani, Kinuko; Takahashi, Shunji; Miura, Yuji; Ikeda, Sadakatsu; Kojima, Yasushi; Watanabe, Kiyotaka; Mochizuki, Hitoshi; Yamaguchi, Hironori; Kawazoe, Yoshimasa; Kashiwabara, Kosuke; Kohsaka, Shinji; Tatsuno, Kenji; Ushiku, Tetsuo; Ohe, Kazuhiko; Yatomi, Yutaka; Seto, Yasuyuki; Aburatani, Hiroyuki; Mano, Hiroyuki; Miyagawa, Kiyoshi; Oda, Katsutoshi.

Cancer Sci ; 114(4): 1710-1717, 2023 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-36601953

11.

Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma.

Kitagawa, Akihiro; Osawa, Tsuyoshi; Noda, Miwa; Kobayashi, Yuta; Aki, Sho; Nakano, Yusuke; Saito, Tomoko; Shimizu, Dai; Komatsu, Hisateru; Sugaya, Maki; Takahashi, Junichi; Kosai, Keisuke; Takao, Seiichiro; Motomura, Yushi; Sato, Kuniaki; Hu, Qingjiang; Fujii, Atsushi; Wakiyama, Hiroaki; Tobo, Taro; Uchida, Hiroki; Sugimachi, Keishi; Shibata, Kohei; Utsunomiya, Tohru; Kobayashi, Shogo; Ishii, Hideshi; Hasegawa, Takanori; Masuda, Takaaki; Matsui, Yusuke; Niida, Atsushi; Soga, Tomoyoshi; Suzuki, Yutaka; Miyano, Satoru; Aburatani, Hiroyuki; Doki, Yuichiro; Eguchi, Hidetoshi; Mori, Masaki; Nakayama, Keiichi I; Shimamura, Teppei; Shibata, Tatsuhiro; Mimori, Koshi.

Br J Cancer ; 128(12): 2206-2217, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-37076565

12.

HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability.

Kawazu, Masahito; Ueno, Toshihide; Saeki, Koichi; Sax, Nicolas; Togashi, Yosuke; Kanaseki, Takayuki; Chida, Keigo; Kishigami, Fumishi; Sato, Kazuhito; Kojima, Shinya; Otsuka, Masafumi; Kawazoe, Akihito; Nishinakamura, Hitomi; Yuka, Maeda; Yamamoto, Yoko; Yamashita, Kazuo; Inoue, Satoshi; Tanegashima, Tokiyoshi; Matsubara, Daisuke; Tane, Kenta; Tanaka, Yosuke; Iinuma, Hisae; Hashiguchi, Yojiro; Hazama, Shoichi; Khor, Seik-Soon; Tokunaga, Katsushi; Tsuboi, Masahiro; Niki, Toshiro; Eto, Masatoshi; Shitara, Kohei; Torigoe, Toshihiko; Ishihara, Soichiro; Aburatani, Hiroyuki; Haeno, Hiroshi; Nishikawa, Hiroyoshi; Mano, Hiroyuki.

Gastroenterology ; 162(3): 799-812, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-34687740

13.

Trib1 promotes acute myeloid leukemia progression by modulating the transcriptional programs of Hoxa9.

Yoshino, Seiko; Yokoyama, Takashi; Sunami, Yoshitaka; Takahara, Tomoko; Nakamura, Aya; Yamazaki, Yukari; Tsutsumi, Shuichi; Aburatani, Hiroyuki; Nakamura, Takuro.

Blood ; 137(1): 75-88, 2021 01 07.

Artigo em Inglês | MEDLINE | ID: mdl-32730594

14.

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.

Matsumura, Yoshihiro; Nakaki, Ryo; Inagaki, Takeshi; Yoshida, Ayano; Kano, Yuka; Kimura, Hiroshi; Tanaka, Toshiya; Tsutsumi, Shuichi; Nakao, Mitsuyoshi; Doi, Takefumi; Fukami, Kiyoko; Osborne, Timothy F; Kodama, Tatsuhiko; Aburatani, Hiroyuki; Sakai, Juro.

Mol Cell ; 60(4): 584-96, 2015 Nov 19.

Artigo em Inglês | MEDLINE | ID: mdl-26590716

15.

NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation.

Hiraike, Yuta; Waki, Hironori; Miyake, Kana; Wada, Takahito; Oguchi, Misato; Saito, Kaede; Tsutsumi, Shuichi; Aburatani, Hiroyuki; Yamauchi, Toshimasa; Kadowaki, Takashi.

PLoS Genet ; 16(9): e1009044, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32991581

16.

Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background.

Muramatsu, Masashi; Osawa, Tsuyoshi; Miyamura, Yuri; Nakagawa, Suguru; Tanaka, Toshiya; Kodama, Tatsuhiko; Aburatani, Hiroyuki; Sakai, Juro; Ryeom, Sandra; Minami, Takashi.

J Biol Chem ; 296: 100697, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33895138

17.

Recommendations related to the analytical equivalence assessment of gene panel testing.

Nagai, Sumimasa; Nishihara, Hiroshi; Suzuki, Takayoshi; Nishio, Kazuto; Taniguchi, Hiroya; Tsuchihara, Katsuya; Nakamura, Kohei; Takamatsu, Reika; Ueno, Toshihide; Aburatani, Hiroyuki; Kohno, Takashi; Kohsaka, Shinji.

Cancer Sci ; 113(10): 3282-3290, 2022 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-35906844

18.

Ubiquitination-dependent and -independent repression of target genes by SETDB1 reveal a context-dependent role for its methyltransferase activity during adipogenesis.

Zhang, Ji; Matsumura, Yoshihiro; Kano, Yuka; Yoshida, Ayano; Kawamura, Takeshi; Hirakawa, Hiroyuki; Inagaki, Takeshi; Tanaka, Toshiya; Kimura, Hiroshi; Yanagi, Shigeru; Fukami, Kiyoko; Doi, Takefumi; Osborne, Timothy F; Kodama, Tatsuhiko; Aburatani, Hiroyuki; Sakai, Juro.

Genes Cells ; 26(7): 513-529, 2021 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-33971063

19.

Tumor mutational burden measurement using comprehensive genomic profiling assay.

Kage, Hidenori; Kohsaka, Shinji; Tatsuno, Kenji; Ueno, Toshihide; Ikegami, Masachika; Zokumasu, Koichi; Shinozaki-Ushiku, Aya; Nagai, Sumimasa; Aburatani, Hiroyuki; Mano, Hiroyuki; Oda, Katsutoshi.

Jpn J Clin Oncol ; 52(8): 925-929, 2022 08 05.

Artigo em Inglês | MEDLINE | ID: mdl-35482395

20.

Functional Evaluation of Human Bioengineered Cardiac Tissue Using iPS Cells Derived from a Patient with Lamin Variant Dilated Cardiomyopathy.

Miura, Koichiro; Matsuura, Katsuhisa; Yamasaki Itoyama, Yu; Sasaki, Daisuke; Takada, Takuma; Furutani, Yoshiyuki; Hayama, Emiko; Ito, Masamichi; Nomura, Seitaro; Morita, Hiroyuki; Toyoda, Masashi; Umezawa, Akihiro; Onoue, Kenji; Saito, Yoshihiko; Aburatani, Hiroyuki; Nakanishi, Toshio; Hagiwara, Nobuhisa; Komuro, Issei; Shimizu, Tatsuya.

Int Heart J ; 63(2): 338-346, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35354754

BVS IEC

Instituto Evandro Chagas

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